Posted: 01 October 2007
Sensitization, glutamate, and the link between migraine and fibromyalgia, Sarchielli P, Di Filippo M, Nardi K, Calabresi P, 2007 Oct., Curr Pain Headache Rep., related MCS studies: Murray 2007.09.29
http://RMForAll.blogspot.com September 29, 2007
"Of course, everyone chooses, as a natural priority, to actively find, quickly share, and positively act upon the facts about healthy and safe food, drink, and environment."
Rich Murray, MA
Room For All
1943 Otowi Road
Santa Fe, New Mexico 87505
Recent research and news re aspartame and stevia: Murray 2007.08.16
Curr Pain Headache Rep. 2007 Oct; 11(5): 343-51.
Sensitization, glutamate, and the link between migraine and fibromyalgia.
Di Filippo M, email@example.com
Calabresi P. firstname.lastname@example.org
University of Perugia
Ospedale Santa Maria della Misericordia, Via Santa Andrea delle Fratte, San Sisto, 06158
Department of Medical and Surgical Specialties and Public Health, Neurologic Clinic, University of Perugia, Perugia, Italy. email@example.com
Recent advances have shed insight on the pathophysiologic mechanisms of fibromyalgia and migraine, especially in the chronic form.
A growing body of evidence supports the involvement of peripheral and central sensitization disturbances of pain-related processes underlying both disorders.
They involve increased glutamate transmission through interaction with its ionotropic and metabotropic receptors.
Few studies supporting the implication of this excitatory amino acid in chronic migraine and primary fibromyalgia demonstrated increased levels of glutamate in the cerebrospinal fluid of affected patients.
These findings have implications for future therapies directed against glutamate receptors (in particular, N-methyl-D-aspartate receptors).
Limited clinical experience in this regard, although promising, does not exclude additional mechanisms contributing to the maintenance of pain, which can be the target of therapeutic approaches in both disorders.PMID: 17894924
[ a reference re Martin L. Pall paradigm fromPosition Statement: Multiple Chemical Sensitivity http://mcs-america.org/MCSPositionStatement.htm
13 Vale Street
Salem, NY 12864
Lourdes Salvador, President firstname.lastname@example.org
Pall, Martin L.
Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome.
Bighampton, NY: The Hawthorne Press. 2007.
Pall, M. Community Spotlight: An Interview with Martin L. Pall, PhD. MCS America News. 2007 Oct;2:10, 11-13.
See also: http://mcs-america.org/pall.pdf
Multiple Chemical Sensitivity: Towards the End of Controversy
Martin L. Pall, Ph.D.
Professor of Biochemistry and Basic Medical Sciences
Washington State University
Pullman, WA 99164-4234 USA
509-335-1246 email@example.com, ]
[ Two years of items by Sarchielli P in PubMed ]
Items 1 - 20 of 81
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Sarchielli P, Di Filippo M, Nardi K, Calabresi P.
Sensitization, glutamate, and the link between migraine and fibromyalgia.
Curr Pain Headache Rep. 2007 Oct;11(5):343-51.
PMID: 17894924 [PubMed - in process]
Sarchielli P, Di Filippo M, Candeliere A, Chiasserini D, Mattioni A, Tenaglia S, Bonucci M, Calabresi P.
Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients.
J Neuroimmunol. 2007 Aug;188(1-2):146-58. Epub 2007 Jul 12.
PMID: 17628700 [PubMed - in process]
Sandrini G, Cerbo R, Del Bene E, Ferrari A, Genco S, Grazioli I, Martelletti P, Nappi G, Pinessi L, Sarchielli P, Tamburro P, Uslenghi C, Zanchin G.
Efficacy of dosing and re-dosing of two oral fixed combinations of indomethacin, prochlorperazine and caffeine compared with oral sumatriptan in the acute treatment of multiple migraine attacks: a double-blind, double-dummy, randomised, parallel group, multicentre study.
Int J Clin Pract. 2007 Aug;61(8):1256-69.
PMID: 17627707 [PubMed - in process]
Free full text in PubMed Central
G Sandrini, 1
R Cerbo, 2
E Del Bene, 3
A Ferrari, 4
S Genco, 5
I Grazioli, 6
P Martelletti, 7
G Nappi, 8
L Pinessi, 9
P Sarchielli, 10
P Tamburro, 11
C Uslenghi, 6
and G Zanchin1 2
This study is registered in the Italian website for the registration of clinical trials (http://oss-sper-clin.sanita.it).
Disclosures Irene Grazioli and Carla Uslenghi are employees of Solvay Pharma S.p.A.
Received April 2007; Accepted April 2007.
The authors wish to acknowledge other investigators from Italy who participated in this study:
Grazia Sances (University Centre for Adaptive Disorders and Headache, IRCCS 'C. Mondino' Institute of Neurology Foundation, Pavia, Italy);
Gianluca Bruti (Pain Centre, Emergency Department, 'La Sapienza' University, Rome);
Francesco De Cesaris (Headache Centre, Department of Internal Medicine, University of Florence);
Maria Pia Prudenzano (Headache Centre, Neurologic Clinic I, University of Bari);
Sergio De Filippis, Gabriella Coloprisco (Regional Referral Headache Centre, Department of Medical Sciences, II School of Medicine, 'La Sapienza' University, Rome);
Lidia Savi (Headache Centre, Neurologic Clinic II, University of Torino);
Cristiana Rossi, Andrea Alberti, Francesca Coppola, Antonio Baldi (Headache Centre, Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia);
Graziella Di Meo (Headache Centre, University of Chieti);
Ferdinando Maggioni, Filippo Dainese (Headache Centre, Department of Neurosciences, University of Padova);
Paolo Liberini (Department of Neurology, Spedali Civili, Brescia);
Giorgio Bono (Department of Neurology, Ospedale di Circolo e Fondazione Macchi, Varese);
Filippo Brighina, Antonina Aloisio (Institute of Neuropsychiatry, University of Palermo);
Giovanni Regesta, Marco Fonzari (Department of Neurology, San Martino Hospital, Genova).
Sarchielli P, Mancini ML, Floridi A, Coppola F, Rossi C, Nardi K, Acciarresi M, Pini LA, Calabresi P.
Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome.
J Pain. 2007 Sep;8(9):737-45. Epub 2007 Jul 5.
PMID: 17611164 [PubMed - in process]
Mattioni A, Paciaroni M, Sarchielli P, Murasecco D, Pelliccioli GP, Calabresi P.
Multiple cranial nerve palsies in a patient with internal carotid artery dissection.
Eur Neurol. 2007;58(2):125-7. Epub 2007 Jun 13. No abstract available.
PMID: 17570922 [PubMed - indexed for MEDLINE]
Mainardi F, Lisotto C, Palestini C, Sarchielli P, Maggioni F, Zanchin G.
Headache attributed to airplane travel ("airplane headache"): first italian case.
J Headache Pain. 2007 Jun;8(3):196-9. Epub 2007 Jun 11.
PMID: 17563837 [PubMed - in process]
Sarchielli P, Zaffaroni M, Floridi A, Greco L, Candeliere A, Mattioni A, Tenaglia S, Di Filippo M, Calabresi P.
Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-beta 1a, and high doses of immunoglobulins.
Mult Scler. 2007 Apr;13(3):313-31. Epub 2007 Jan 29.
PMID: 17439900 [PubMed - indexed for MEDLINE]
Sarchielli P, Pedini M, Coppola F, Rossi C, Baldi A, Corbelli I, Mancini ML, Calabresi P.
Application of the ICHD-II criteria to the diagnosis of primary chronic headaches via a computerized structured record.
Headache. 2007 Jan;47(1):38-44.
PMID: 17355492 [PubMed - indexed for MEDLINE]
Calabresi P, Galletti F, Rossi C, Sarchielli P, Cupini LM.
Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms.
Trends Pharmacol Sci. 2007 Apr;28(4):188-95. Epub 2007 Mar 6. Review.
PMID: 17337068 [PubMed - indexed for MEDLINE]
Mancini ML, Stracci F, Tambasco N, Sarchielli P, Rossi A, Calabresi P.
Prevalence of essential tremor in the territory of Lake Trasimeno, Italy: results of a population-based study.
Mov Disord. 2007 Mar 15;22(4):540-5.
PMID: 17260338 [PubMed - indexed for MEDLINE]
Sarchielli P, Pini LA, Coppola F, Rossi C, Baldi A, Mancini ML, Calabresi P.
Endocannabinoids in chronic migraine: CSF findings suggest a system failure.
Neuropsychopharmacology. 2007 Jun;32(6):1384-90.
Epub 2006 Nov 22. Erratum in: Neuropsychopharmacology. 2007 Jun;32(6):1432.
PMID: 17119542 [PubMed - indexed for MEDLINE]
Tenaglia S, Paciaroni M, Hamam M, Sarchielli P, Pelliccioli GP, Calabresi P.
Giant basilar apex aneurysm presenting as bilateral thalamic compression with neuropsychological disorders.
Eur Neurol. 2006;56(1):57-8. Epub 2006 Aug 17. No abstract available.
PMID: 16921245 [PubMed - indexed for MEDLINE]
Sarchielli P, Floridi A, Mancini ML, Rossi C, Coppola F, Baldi A, Pini LA, Calabresi P.
NF-kappaB activity and iNOS expression in monocytes from internal jugular blood of migraine without aura patients during attacks.
Cephalalgia. 2006 Sep;26(9):1071-9.
PMID: 16919057 [PubMed - indexed for MEDLINE]
Trigger factors of migraine and tension-type headache.
J Headache Pain. 2006 Sep;7(4):172-3. No abstract available.
PMID: 16897623 [PubMed - indexed for MEDLINE]
Sarchielli P, Mancini ML, Calabresi P.
Practical considerations for the treatment of elderly patients with migraine.
Drugs Aging. 2006;23(6):461-89. Review.
PMID: 16872231 [PubMed - indexed for MEDLINE]
Sarchielli P, Alberti A, Candeliere A, Floridi A, Capocchi G, Calabresi P.
Glial cell line-derived neurotrophic factor and somatostatin levels in cerebrospinal fluid of patients affected by chronic migraine and fibromyalgia.
Cephalalgia. 2006 Apr;26(4):409-15.
PMID: 16556241 [PubMed - indexed for MEDLINE]
Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L, Floridi A, Calabresi P.
Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally.
Headache. 2006 Feb;46(2):200-7.
PMID: 16492228 [PubMed - indexed for MEDLINE]
Sarchielli P, Pini LA, Zanchin G, Alberti A, Maggioni F, Rossi C, Floridi A, Calabresi P.
Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders.
Cephalalgia. 2006 Mar;26(3):257-65.
PMID: 16472331 [PubMed - indexed for MEDLINE]
Pini LA, Guidetti G, Brovia D, Pontremoli P, Sarchielli P.
Topo-kinesthetic memory in chronic headaches. A new test for chronic patients: preliminary report.
J Headache Pain. 2005 Dec;6(6):448-54. Epub 2005 Nov 10.
PMID: 16388339 [PubMed - indexed for MEDLINE]
Sarchielli P, Pedini M, Alberti A, Rossi C, Baldi A, Corbelli I, Calabresi P.
Application of ICHD 2nd edition criteria for primary headaches with the aid of a computerised, structured medical record for the specialist.
J Headache Pain. 2005 Sep;6(4):205-10.
PMID: 16362665 [PubMed - indexed for MEDLINE]
13 mainstream research studies in 24 months showing aspartame toxicity, also 3 relevant studies on methanol and formaldehyde: Murray 2007.08.17
19,000 people, the 4% of users of aspartame who drink average 5 cans daily, have more problems in NIH AARP study of 474,000 people: Murray 2007.09.21
http://RMForAll.blogspot.com September 21, 2007
Nurses Health Study can quickly reveal the extent of aspartame (methanol, formaldehyde, formic acid) toxicity: Murray 2004.11.21
The Nurses Health Study is a bonanza of information about the health of probably hundreds of nurses who use 6 or more cans daily of diet soft drinks -- they have also stored blood and tissue samples from their immense pool of subjects, over 100,000 for decades.
This first page of a long review appreciates details in Unhee Lim study: bias, omissions, incuriosity = opportunity, aspartame safety evaluation, Magnuson BA, Burdock GA, Williams GM, 7 more, 2007 Sept, Ajinomoto funded 98 pages html [$ 32 781888262_content.pdf]: Murray 2007.09.17
4 cases of aspartame-induced thrombocytopenia [ very low platelets in blood ], HJ Roberts MD, Letter in Southern Medical Journal 2007 May: 100(5); 543: Murray 2007.08.25
Formaldehyde induced urticarial vasculitis in male medical student, age 40, Michael Pellizzari, Gillian Marshman, Flinders U., Australasian J. Dermatol. 2007 Aug: Murray 2007.08.29
Highly toxic formaldehyde, the cause of alcohol hangovers, is made by the body from 100 mg doses of methanol from dark wines and liquors, dimethyl dicarbonate, and aspartame: Murray 2007.08.31
New details on how formaldehyde and formic acid from methanol are neurotoxic: Chun Lai Nie, Rong Giao He, et al, PLoS ONE 2(7): e629
2007.07.18 Chinese Academy of Sciences, Beijing: Murray 20097.09.01
Aspartame bans, tis more an avalanche than a trend...: Rich Murray 2007.08.17
[ see also: http://groups.yahoo.com/group/aspartameNM/message/1458
ASDA, Wal-Mart's UK supermarket chain, bans artificial colors, transfats, MSG and aspartame, Marguerite Kelly, The Washington Post: Murray 2007.08.03 ]
So far, USA print and broadcast media are deaf, blind, and dumb, regarding recent major bans of aspartame and MSG in the UK and EU.
The EU Parliament voted July 12 to ban artificial sweeteners in newly born and infant foods.
On May 15 four huge UK supermarket chains announced bans of aspartame and MSG, food dyes, and many additives to protect kids from ADHD -- Sainsbury, Tesco, Marks & Spencer, and ASDA, a unit of WalMart.
May 31: Coca-Cola and the much larger Cargill Inc., after years of secret development, with 24 patents, will soon sell rebiana (stevia) in drinks and food in the many nations where it is approved as a sweetener -- for decades a major sweetener in Japan, China, Korea, Taiwan, Thailand, Malasia, Saint Kitts, Nevis, Brazil, Peru, Paraguay, Uruguay, and Israel, and an approved supplement in USA, Australia, and Canada, according to Wikipedia.
Aspartame Controversy, in Wikipedia democratic encyclopedia, 72 references (including AspartameNM # 864 and 1173 by Murray, brief fair summary of much more research: Murray 2007.01.01
Souring on fake sugar (aspartame), Jennifer Couzin, Science 2007.07.06: 4 page letter to FDA from 12 eminent USA toxicologists re two Ramazzini Foundation cancer studies 2007.06.25: Murray 2007.07.18
Artificial sweeteners (aspartame, sucralose) and coloring agents will be banned from use in newly-born and baby foods, the European Parliament decided: Latvia ban in schools 2006: Murray 2007.07.12
Stevia to be approved and cyclamates limited by Food Standards Australia New Zealand: >JMC Geuns critiques of two recent stevia studies by Nunes: Murray 2007.05.29
More from The Independent, UK, Martin Hickman, re ASDA (unit of Wal-Mart Stores) and Marks & Spencer ban of aspartame, MSG, artificial chemical additives and dyes to prevent ADHD in kids: urray 2007.05.16
ASDA (unit of Wal-Mart Stores WMT.N) and Marks & Spencer will join Tesco and also Sainsbury to ban and limit aspartame, MSG, artificial flavors dyes preservatives additives, trans fats, salt "nasties" to protect kids from ADHD: leading UK media: Murray 2007.05.15
Coca-Cola and Cargill Inc., after years of development, with 24 patents, will soon sell rebiana (stevia) in drinks and foods: Murray 2007.05.31
http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed search PubMed