Posted: 15 July 2010
WC Monte gives 1917 rabbit study that shows blood vessel thickening by formic acid, made by ADH in many tissues from methanol -- sources are canned fruits, wood & tobacco smoke, alcohol drinks, aspartame: Rich Murray 2010.07.04
Sunday, July 4, 2010
[at end of each long page, click on Older Posts]
Yes there is a lot of thickening of connective tissue lining the vessels of individuals poisoned with methanol who live long enough for the changes to occur. This is to be expected since the layers of the veins and arteries that contain ADH are indeed the the ones that are involved in thickening. I have attached an article from 1917 -- take a look at page 770.
Woody 2010.07.03 12:36 PM MST
"My impression is that the apparent increase of the connective tissue is due not only to the fact that the parenchyma cells have disappeared, but to the actual proliferation of the fixed tissue cells, as seen by the very marked thickening of the adventitia and the media of the blood-vessels."
'In cases of long standing, in addition to the above general appearance there is also a marked increase of the connective tissue, especially around the blood-vessels."
589 references -- click on each title for free full pdf
15 Eisenberg AA.; 1917. "Visceral Changes in Wood Alcohol Poisoning by Inhalation", American Journal of Public Health 7:765
http://whilesciencesleeps.com/references/pdf/15 7 pages
[This is the time before Roe when it was unknown that humans were many times more sensitive to methanol than any other animal.
Keen eyes, a century ago, noted a progression of horrors in a variety of tissues -- worth quoting at length.]
Arthur Alexander Eisenberg, BA, MD
Director, Pathological Laboratories, St. Vincent's Charity Hospital, Cleveland.
"But Pohl (8) observed experimentally that while no bad effects followed immediately after the administration to an animal of a small dose of methyl alcohol, very serious results were noticeable a few days later, the experiment in many instances terminating fatally. If a small non-lethal dose be repeated a few times, fatal issue occurs invariably, while ethyl alcohol, similarly administered, produces no such effects.
How are we to explain such paradoxical phenomenon? Why does a substance, non-lethal in a single dose, become lethal after a few repeated doses, and vice versa? The explanation as given by Pohl is as follows: Ethyl alcohol is very rapidly oxidized in the animal body, in fact so rapidly that over 90 per cent. of it is converted to carbon dioxide and water, whereas methyl alcohol is oxidized very slowly, with the formation of formaldehyde and then formic acid.
It is formic acid and its cumulative action that is responsible for the untoward effects of methyl alcohol, the variability of individual results depending on the individual power of oxidation, the action of wood alcohol thus becoming especially dangerous in those who are ill nourished...
The histo-chemical investigations of Placet (9) show that the power of fixing methyl alcohol varies with the different tissues, the following organs being given in the order of their affinity: brain, liver, kidney and muscles. This statement of Placet finds abundant confirmation in the results of my experiments...
The most striking observation was the uniformity of lesions (practically in every case the same organs, and those only, were involved), the extent of lesions varying with the duration of time exposure, thus the fatty degeneration of the cardiac muscle or destruction of the perenchyma cells of the cerebrum being more extensive in the rabbit which had been exposed for 6 months than in the one which had inhaled wood alcohol or Columbian spirits [more refined] for but 2 months...
...the central nervous system -- notably the cerebrum -- appears to bear the brunt of the attack, it being together with the optic nerve the most frequently as well as the most extensively involved organ. Next in frequency, but not necessarily in extent, of involvement are the kidneys, the liver, and the muscle -- the latter again showing a very marked inequality of involvement, the cardiac muscle being affected in every case while the striated and the smooth muscle were involved but in 10 per cent. of the cases...no difference between the effects of wood alcohol when imbided and when inhaled.
The lesions found in the various parts of the cerebrum, the cerebellum, the medulla and the pons consisted of different degrees of inflammatory and degenerative processes. Macroscopically the tissues appear yellowish, glistening; the line of demarcation between the grey and the white matter is not as sharp as in the control animals, in the more prolonged cases the gray matter appearing quite thinned -- the entire picture being one of a nonspecific atrophy.
Microscopically, the neurocytes are diminished, assuming a spindle-like shape, Nissl's granules also are diminished, with brownish pigment scattered here and there.
In the more severe cases the parenchyma cells are greatly reduced in numbers as well as in size. Thus, for example, the brain of the rabbit which had been exposed to the inhalation of Columbian Spirits showed practically nothing but neuroglia cells, and no trace of parenchyma cells, the latter being represented by masses of granular debris and fat droplets, partly taken up by the so-called contractile cells, i.e. leucocytes, lymphocytes, and according to Birch-Hirschfield, endothelial cells.
The different states of parenchymatous degeneration depend, of course, on the length of the exposure to which the animal has been subjected, the nuclear changes varying from the wandering of the nucleus to the periphery of the cell to the total karyolysis.
My impression is that the apparent increase of the connective tissue is due not only to the fact that the parenchyma cells have disappeared, but to the actual proliferation of the fixed tissue cells, as seen by the very marked thickening of the adventitia and the media of the blood-vessels.
The entire microscopical picture corresponds very closely to Adami's "exhaustion" condition, which is "anatomically recognized by the disappearance of cells and fibres and the secondary overgrowth of glial tissue filling in the space."
The lesions of the liver and the kidney present, both macroscopically and microscopically, the typical characteristic of albuminous degeneration (cloudy swelling) and fatty degeneration -- the increased size of the organ, softened consistence, the tissue being almost friable (etat crible), glistening yellowish color, the protoplasm being uniformly dull-grey, the outline of the cells in most cases being altered or lost. The nuclei are much smaller than they normally are, lost in many cases, and appearing as vague, shadowy structures in others. The cell bodies are filled with granular, dust-like masses.
In cases of long standing, in addition to the above general appearance there is also a marked increase of the connective tissue, especially around the blood-vessels.
The muscle cells, especially the heart, present an appearance very similar to that of the liver and the kidney, as well as both fragmentation and segmentation, in some of the cases.
The lung shows in many cases patches of broncho-pneumonia, which, however, are not uniform, either in distribution or in extent."
Woodrow C Monte, PhD, Emiritus Prof. Nutrition gives many PDFs of reseach -- methanol (11% of aspartame) puts formaldehyde into brain and body -- multiple sclerosis, Alzheimer's, cancers, birth defects, headaches: Rich Murray 2010.05.13
Thursday, May 13, 2010
[Other formaldehyde sources include alcohol drinks and tobacco and wood smoke, while adequate folic acid levels protect most people, but not for brain and retina harm.
Methanol: Where Is It Found? How Can It Be Avoided?
AVOID the following, ranked in order of greatest danger:
589 references -- click on each title for free full pdf
Article 2 http://www.thetruthaboutstuff.com/review2.html
Selection from Article 2, Fitness Life, December 2007, and well discussed in the DVD video:
"Identical Symptoms of MS, Methanol Poisoning and Aspartame Toxicity
The symptoms of multiple sclerosis (44, 83, 85, 169), chronic and acute methanol poisoning (13, 144, 189), and Aspartame toxicity (54, 58, 93, 181), are in all ways identical.
There is nothing that happens to the human body from the toxic effect of methanol that has not been expressed during the course of MS... nothing (143, 144).
This generalization extends even to the remarkable opthomological conditions common to both: transitory optic neuritis and retrolaminar demyelinating optic neuropathy with scotoma of the central visual field (which occasionally manifests as unilateral temporary blindness (85, 138, 163).
In fact, these opthomological symptoms have been thought of for years in their respective literatures to be "tell tale" indications for the differential diagnosis for each of these maladies independently (85, 138, 148, 163, 169).
The common symptoms of
Headache (13, 83, 181, 189)
Nervousness (13, 83, 181)
Depression (58, 83, 189, 181)
Memory loss (18, 147, 85, 169, 181)
Tingling sensations (13, 85, 168, 138, 169)
Pain in the extremities (13, 85, 169)
Optic neuritis (85, 138, 148, 163, 169)
Bright lights in the visual field (139, 83)
Seizures (21, 83, 160)
Inability to urinate or to keep from urinating (139, 146, 167)
Are all shared by each of these conditions and shared yet again by complaints from aspartame poisoning (54, 58, 93, 181).
I take these strikingly similar symptom patterns as evidence that these disorders act on identical components of the central nervous system and in the same way.
The "Miracle" that MS shares with Methanol poisoning
In the early stages of MS, or when a non-lethal dose of methanol has been administered, complete recovery is a possibility.
The only two afflictions for which such dramatic "remissions" are reported from identical neuromuscular and opthomological damage, even "blindness" is relapsing-remitting multiple sclerosis (85) and methyl alcohol poisoning (138, 163).
The pathology of the two maladies is in may ways identical, particularly when it comes to destruction of the myelin sheath with no harm to the axon itself (18, 148, 176).
Sex Ratios for MS and Aspartame Reactions
Women bear the brunt of multiple sclerosis (91a-c) and lupus (SLE)(73) with fully three-fold representations in infliction numbers over men for both diseases.
This is exactly the proportion represented by adverse reactors to Aspartame reported by the US Center for Disease Control in their study of 1984(58).
The Center found three women to every man whose Aspartame consumption complaints were serious enough to warrant investigation (93).
Although the female/male ratio for those stricken with MS has always been high, recent estimates place it at over 3 to 1 (91, 91a, 91c).
What might account for the difference across sexes in incidence?
A study published in the New England Journal of Medicine (94) reports biopsies of the gastric lining of men and women.
A result was that the concentration of ADH in the gastric lining of men was much higher than for woman.
Men have the advantage of removing methanol from the bloodstream four times faster on an equal-body-size basis than women.
Thus, for men, methanol is more likely to be removed from the blood before it reaches the brain.
The brain is spared but the methanol removed would still be metabolized to formaldehyde in the gut where it would reap its havoc on a more forgiving organ.
This may help explain why men have more gastrointestinal complaints from both methanol and Aspartame consumption (93, 99).
On the other hand, women's complaints from both more frequently involve serious neurological complications."
Role of formaldehyde, made by body from methanol from foods and aspartame, in steep increases in fetal alcohol syndrome, autism, multiple sclerosis, lupus, teen suicide, breast cancer, Nutrition Prof. Woodrow C. Monte, retired, Arizona State U., two reviews, 190 references supplied, Fitness Life, New Zealand 2007 Nov, Dec: Murray 2007.12.26
Monte WC., Is your Diet Sweetener killing you?
Fitness Life. 2007 Nov; 33: 31-33.
Monte WC., A Deadly Experiment.
Fitness Life. 2007 Dec; 34: 38-42.
Monte WC., Bittersweet: Aspartame Breast Cancer Link.
Fitness Life. 2008 Feb; 34: 21-22.
Article 1 http://www.thetruthaboutstuff.com/review1.html
Article 2 http://www.thetruthaboutstuff.com/review2.html
Article 3 http://www.thetruthaboutstuff.com/review3.html
223 references with abstracts or full and partial texts
Methanol (11% of aspartame), made by body into formaldehyde in many vulnerable tissues, causes modern diseases of civilization, summary of a century of research, Woodrow C Monte PhD, Medical Hypotheses journal: Rich Murray 2009.11.15
Sunday, November 15, 2009
Methanol: A Chemical Trojan Horse as the Root of the Inscrutable U, Prepublication Copy; Medical Hypotheses -- 06 November 2009 (10.1016/j.mehy.2009.09.059)
Woodrow C. Monte PhD
Professor of Food Science (retired)
Arizona State University
corresponding author : Woodrow C. Monte PhD
470 South Rainbow Drive
Page, Arizona 86040
Key Words: food epidemiology; diseases of civilization; methanol; formaldehyde; aspartame; autism; multiple sclerosis; Alzheimer's; U-shaped curve.
Until 200 years ago, methanol was an extremely rare component of the human diet and is still rarely consumed in contemporary hunter and gatherer cultures. With the invention of canning in the 1800s, canned and bottled fruits and vegetables, whose methanol content greatly exceeds that of their fresh counterparts, became far more prevalent.
The recent dietary introduction of aspartame, an artificial sweetener, 11% methanol by weight, has also greatly increased methanol consumption. Moreover, methanol is a major component of cigarette smoke, known to be a causative agent of many diseases of civilization (DOC).
Conversion to formaldehyde in organs other than the liver is the principal means by which methanol may cause disease. The known sites of class I alcohol dehydrogenase (ADH I), the only human enzyme capable of metabolizing methanol to formaldehyde, correspond to the sites of origin for many DOC. Variability in sensitivity to exogenous methanol consumption may be accounted for in part by the presence of aldehyde dehydrogenase sufficient to reduce the toxic effect of formaldehyde production in tissue through its conversion to the much less toxic formic acid.
The consumption or endogenous production of small amounts of ethanol, which acts as a competitive inhibitor of methanol's conversion to formaldehyde by ADH I, may afford some individuals protection from DOC.
Old tiger roars -- Woodrow C Monte, PhD -- aspartame causes many breast cancers, as ADH enzyme in breasts makes methanol from diet soda into carcinogenic formaldehyde -- same in dark wines and liquors, Fitness Life 2008 Jan.: Murray 2008.02.11
Monday, February 11, 2008
Aspartame: Methanol and the Public Interest 1984: Monte: Murray 2002.09.23
Dr. Woodrow C. Monte
Aspartame: methanol, and the public health.
Journal of Applied Nutrition 1984; 36 (1): 42-54
. (62 references) Professsor of Food Science [retired 1992]
Arizona State University, Tempe, Arizona 85287
The methanol from 2 L of diet soda, 5.6 12-oz cans, 20 mg/can, is 112 mg, 11% of the aspartame. The EPA limit for water is 7.8 mg daily for methanol (wood alcohol), a deadly cumulative poison. Many users drink 1-2 L daily. The reported symptoms are entirely consistent with chronic methanol toxicity. (Fresh orange juice has 34 mg/L, but, like all juices, has 16 times more ethanol, which strongly protects against methanol.)
"The greater toxicity of methanol to man is deeply rooted in the limited biochemical pathways available to humans for detoxification. The loss of uricase (EC 188.8.131.52.), formyl-tetrahydrofolate synthetase (EC 184.108.40.206.) (42) and other enzymes (18) during evolution sets man apart from all laboratory animals including the monkey (42).
There is no generally accepted animal model for methanol toxicity (42, 59).
Humans suffer "toxic syndrome" (54) at a minimum lethal dose of <1 gm/kg, much less than that of monkeys, 3-6 g/kg (42, 59).
The minimum lethal dose of methanol in the rat, rabbit, and dog is 9.5, 7.0 , and 8.0 g/kg, respectively (43); ethyl alcohol is more toxic than methanol to these test animals (43)."
"Label present in liver, plasma and kidney was in the range of 1-2 % of total radioactivity administered per g or mL, changing little with time. Other organs (brown and white adipose tissues, muscle, brain, cornea and retina) contained levels of label in the range of 1/12th to 1/10th of that of liver. In all, the rats retained, 6 hours after administration, about 5 % of the label, half of it in the liver."
7 Trocho C. Pardo R. Fafecas I. Virgili J. Remesar X. Fernandez-Lopez. J;
"A.1988. Formaldehyde derived from dietary aspartame binds to tissue components in vivo", Life Sci 63: 337
http://whilesciencesleeps.com/references/pdf/7 13 pages
Adult male rats were given an oral dose of 10 mg/kg aspartame, 14C-labeled in the methanol carbon. At timed intervals of up to 6 hours, the radioactivity in plasma and several organs was investigated. Most of the radioactivity found (>98 % in plasma, >75 % in liver) was bound to protein. Label present in liver, plasma and kidney was in the range of 1-2 % of total radioactivity administered per g or mL, changing little with time. Other organs (brown and white adipose tissues, muscle, brain, cornea and retina) contained levels of label in the range of 1/12th to 1/10th of that of liver. In all, the rats retained, 6 hours after administration, about 5 % of the label, half of it in the liver.
The specific radioactivity of tissue protein, RNA and DNA was quite uniform. The protein label was concentrated in amino acids, different from methionine, and largely coincident with the result of protein exposure to labeled formaldehyde. DNA radioactivity was essentially in a single different adduct base, different from the normal bases present in DNA. The nature of the tissue label accumulated was, thus, a direct consequence of formaldehyde binding to tissue structures.
The administration of labeled aspartame to a group of cirrhotic rats resulted in comparable label retention by tissue components, which suggests that liver function (or its defect) has little effect on formaldehyde formation from aspartame and binding to biological components.
The chronic treatment of a series of rats with 200 mg/kg of non-labeled aspartame during 10 days results in the accumulation of even more label when given the radioactive bolus, suggesting that the amount of formaldehyde adducts coming from aspartame in tissue proteins and nucleic acids may be cumulative.
It is concluded that aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts. PMID: 9714421
From: Rich Murray [mailto:firstname.lastname@example.org]
Sent: Friday, July 02, 2010 8:06 PM
To: Woodrow Monte
Cc: Rich Murray; RichMurray.email@example.com
Subject: neck vein narrowing & MS -- any methanol connection? Monte: Murray 2010.07.02
Neck vein narrowing & MS -- any methanol connection? Monte: Murray 2010.07.02
June 28, 2010
From M.S. Patients, Outcry for Unproved Treatment
By DENISE GRADY
For her first appointment with Dr. Daniel Simon, Neelima Raval showed up with a rolling file cabinet full of documents. She had downloaded every word written by or about Dr. Paolo Zamboni, a vascular surgeon from Italy with a most unorthodox theory about multiple sclerosis.
Dr. Zamboni believes that the disease, which damages the nervous system, may be caused by narrowed veins in the neck and chest that block the drainage of blood from the brain. He has reported in medical journals that opening those veins with the kind of balloons used to treat blocked heart arteries-an experimental treatment he calls the "liberation procedure" -- can relieve symptoms....
She has a degree in toxicology and works for a drug company...
Dr. Zamboni, 53, (no relation to the inventor of the ice-rink machine) began studying the medical literature on multiple sclerosis in 1995 when his wife learned she had the disease.
"What I found was like a detective story," he said.
He discovered reports of vein abnormalities and of brain lesions forming around veins. But the research had been abandoned. Vein disorders are his specialty; he has been studying them for 25 years. He began using ultrasound and other imaging techniques to examine veins, and found narrowings in the neck and chest veins in people with the disease, but not in healthy ones. He suspected that abnormal blood flow and pressure in the veins -- not just narrowing alone -- might cause minute amounts of bleeding in the brain, leading to an immune reaction and inflammation that damaged myelin and nerves. Iron deposits could also form, and add to the damage. He wondered if opening the narrowed areas might help. In 2006 he began using balloons to treat patients, including his wife, whose symptoms went away and, he says, have not come back....
Int Angiol. 2010 Apr;29(2):140-8.
CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies: a pilot study.
Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojnacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, Ramanathan M, Zivadinov R.
Vascular Diseases Center, University of Ferrara-Bellaria Neurosciences,
Ferrara and Bologna, Italy.
Paolo Zamboni, firstname.lastname@example.org
Rich Murray, MA
Boston University Graduate School 1967 psychology
BS MIT 1964, history and physics
1943 Otowi Road
Santa Fe, New Mexico 87505
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