MEDICATION RISKS TO CONSUMERS
By H. J. Roberts, M.D., F.A.C.P., F.C.C.P.
(c)2007 by H. J. Roberts, M.D.
Originally appeared in: Nutrition Health Review The Consumer's Medical Journal, January 2008
Consumerism, a characteristic feature of contemporary society, is generally regarded as an advantage from industrial and economic growth. It tends to be equated with "life, liberty and the pursuit of happiness." Unfortunately, risks are incurred when the search for greater comfort, health and longevity is promoted by misleading hype, greed, and peer pressure. Insofar as the potential dangers are largely ignored or unrecognized, they threaten mankind. This (article) deals with topics that remain highly controversial but have profound public health consequences:
The current pharmaceuticalization of our population warrants attention. I regret the excessive use of many drugs and "supplements" by generation Rx" that has been fostered by duped physicians and expensive campaigns. The resulting problems include toxicity, addiction and drug interactions.
- The prodigious and unrestrained consumption of Vitamin E
- The widespread use of statin drugs to lower cholesterol levels
- The ravages of "fear of fat," particularly among young women
- The lack of awareness of light and radiation stress
The feats of pharmaceutical research and development admittedly have been remarkable. They must be tempered, however, by the adverse effects of potent drugs -- whether through use, abuse or negligence on the part of the prescribing doctors.
Years may lapse before awareness of the unsuspected serious risks of widely promoted drugs develop, even after they became available without prescription. Examples are (a) the risk of a Vitamin B 12 depletion from the chronic use of drugs that suppress gastric acid (particularly proton pump inhibitors) and (b) the risk of infection from Clostridium difficile (a cause of life threatening diarrhea) from using nonsteroidal anti-inflammatory agents.2
- Revelations about articles published in major medical journals, pertaining to cross conflicts of interest and ghostwriting have been disturbing.
- Richard Horton, a respected editor of "The Lancet, commented in 2004 that such contributions "have developed into information laundering operations" for this industry.
* The pharmaceutical industry funds an estimated 60 percent of all
continuing medical education in the United States.1
The safety of new drugs should require close postmarketing surveillance, limited direct-to-consumer advertising, a special symbol on packaging (as a black triangle), a database on all clinical trials and mandatory review after five years by the FDA's Center for Drug Evaluation and Research. A major problem heretofore has been the setting up of studies to showcase a drug's benefits while obscuring side effects -- as "non-serious events" with the statins.
Some pharmaceutical companies are now advertising medical conditions directly to the public as diseases that require drug treatment. This state of affairs has been termed "selling sickness"3 Examples are Attention Deficit Disorder, premenstrual tension, osteoporosis, slight arthritis pain and isolated elevated cholesterol levels. But the enticing pitch usually glosses over potentially serious side effects. In fact, the withdrawal of Vioxx (rofecoxib) came as an embarrassment when it was learned that severe cardiovascular reactions noted in clinical trials had been overlooked and understated. There also must be extreme doubt about the safety of pharmacologic innovations when the line between drugs and foods/additives is blurred. An illustration is the introduction of chemicals that block receptors in the mouth to enhance taste.
Excerpt taken from Protecting Mankind: One Physician's Quest by H. J. Roberts, M./D. (C) 2007. Reprinted by permission from the author and from Sunshine Sentinel Press, Inc. Dr. Roberts is a Board-certified internist and has been the Director of the Palm Beach Institute for Medical Research since l964. He is on the Emeritus staff of Good Samaritan Hospital and St. Mary's Hospital and is a member of several medical and scientific organizations.
- Elliott, C. Should journals publish industry-funded bioethics articles? The Lancet, 2005,366:422-424
- Dial, S., et al. Use of gastric acid suppressive agents and the risk of community-acquired Clostridium-difficile associated disease. Journal of the American Medical Association, 2005;294:2989-2995.
- Moynihan, R., and Cassels, A Selling Sickness: How the World's Pharmaceutical Companies Are Turning Us All Into Patients. New York: Nation Books; 2005