Posted: 23 March 2011
Aspartame water in rats for 6 months causes liver harm, RH Nair et al, Mahatma Gandhi U, Food Chem Toxicol 2011.03.02: Rich Murray 2011.03.12
http://rmforall.blogspot.com/2011_03_01_archive.htm
Saturday, March 12, 2011
http://groups.yahoo.com/group/aspartameNM/message/1620
http://www.ncbi.nlm.nih.gov/pubmed/21376768
Food Chem Toxicol. 2011 Mar 2. [Epub ahead of print]
Effect of long term intake of aspartame on antioxidant defense status in liver.
Abhilash M, Paul MV, Varghese MV, Nair RH.
School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India, 686560.
Abstract
The present study evaluates the effect of long term intake of aspartame, the artificial sweetener, on liver antioxidant system and hepatocellular injury in animal model.
Eighteen adult male Wistar rats, weighing 150 - 175 g, were randomly divided into three groups as follows: first group was given aspartame dissolved in water in a dose of 500 mg/kg.b.wt; the second group was given a dose of 1000 mg/kg.b.wt; and controls were given water freely.
Rats that had received aspartame (1000 mg/kg.b.wt) in the drinking water for 180 days showed a significant increase in activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and y-glutamyl transferase (GGT).
The concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx), and glutathione reductase (GR) were significantly reduced in the liver of rats that had received aspartame (1000 mg/kg.b.wt).
Glutathione was significantly decreased in both the experimental groups. Histopathological examination revealed leukocyte infiltration in aspartame-treated rats (1000 mg/kg.b.wt).
It can be concluded from these observations that long term consumption of aspartame leads to hepatocellular injury and alterations in liver antioxidant status mainly through glutathione dependent system.
Copyright 2011. Published by Elsevier Ltd. PMID: 21376768
Souganth Paul, MV - Research Fellow
Abhilash, M - Research Fellow
Mathews V Varghese - Research Fellow
http://www.mgu.ac.in/index.php?option=com_content&view=article&id=493&Itemid=96
School of Bio-Sciences Teacher Profiles
Name: Dr. R. Harikumaran Nair
Designation: Assistant Professor
Address: Room No. 5
School of Biosciences,
Mahatma Gandhi University
Priyadarshini Hills. P O., Kottayam-686 560
Kerala, India
Phone: +91-481-2731035 Extension: 16
Mobile Phone: +91-94472 60362
Home page: http://www.biophysiol.org
Research Interest
In our laboratory, we study the effect of food additives such as monosodium glutamate, aspartame, drug component arsenic trioxide and other toxins like organic solvents on different physiological mechanisms in rats and tissue culture model systems. Another area of interest is environmental and occupational stress.
Academic Profile
Ph.D - Physiology (2001), School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India
M.Sc - Zoology (1994) University of Kerala, Thiruvananthapuram, Kerala, India
B.Sc - Zoology (1992) University of Kerala, Thiruvananthapuram, Kerala, India
Professional Experience:
Sagi, TM - Research Fellow
Souganth Paul, MV - Research Fellow
Abhilash, M - Research Fellow
Mathews V Varghese - Research Fellow
Manju Alex - Research Fellow
Publications:
Scientific Proceedings
Prediction Equation for Lung Functions in South Indian Children.
Ind.J.Physiol.Pharmacol.1997; 41(4):390-396.
Pulmonary Function Studies in Rowers.
Ind.J.Physiol.Pharmacol.1997; 41(1):29-34.
Effect of Domestic Cooking Fuels on Lung Function in Women.
Pollution Research 1997;16(3):149-154.
Copyright 2010 MG University, All Rights Reserved. Content by PRD.
Supported by System Administration Team, M.G. University
_______________________________________________
Careful expert lifetime study on mice shows liver and lung cancers from aspartame, M Soffritti et al, Ramazzini Institute, Italy, checked by US National Toxicology Program experts, confirms many previous studies from 2001 on: Rich Murray 2011.02.27
http://rmforall.blogspot.com/2011_02_01_archive.htm
Sunday, February 27, 2011
http://groups.yahoo.com/group/aspartameNM/message/1619
Re GC Ebers study, females harmed more by body making methanol into formaldehyde in brain via ADH enzyme: 589 references, WC Monte, retired Prof. Nutrition: Rich Murray 2011.01.08
http://rmforall.blogspot.com/2011_01_01_archive.htm
Saturday, January 8, 2011
http://groups.yahoo.com/group/aspartameNM/message/1614
Woodrow C Monte, PhD, Emiritus Prof. Nutrition gives many PDFs of research -- methanol (11% of aspartame) puts formaldehyde into brain and body -- multiple sclerosis, Alzheimer's, cancers, birth defects, headaches: Rich Murray 2010.05.13
http://rmforall.blogspot.com/2010_05_01_archive.htm
Thursday, May 13, 2010
http://groups.yahoo.com/group/aspartameNM/message/1601
[Other formaldehyde sources include alcohol drinks and tobacco and wood smoke, while adequate folic acid levels protect most people.]
http://whilesciencesleeps.com/about
http://while-science-sleeps.com/references/pdf/586
[summary, not peer reviewed]
Monte WC.
Methanol: A chemical Trojan horse as the root of the inscrutable U. Medical Hypotheses 2010;74(3):493-6
DOI 2010.10.16
Monte WC.
Bittersweet: Aspartame Breast Cancer Link.
Fitness Life 2008 Jan. 34: 32-36
Monte WC.
A Deadly Experiment. Methanol and MS
Fitness Life 2007 Dec. 34: 36-41
Monte WC.
Sickly Sweet: Is your Diet Sweetener killing you?
Fitness Life 2007 Nov. 33: 31-33
http://whilesciencesleeps.com/references
589 references for above articles and upcoming book
http://whilesciencesleeps.com/montediet
[and Fitness Life 2007 Dec. 34: 36-41]
Methanol: Where Is It Found? How Can It Be Avoided?
AVOID the following, ranked in order of greatest danger:
"Identical Symptoms of MS, Methanol Poisoning and Aspartame Toxicity
The symptoms of multiple sclerosis (44, 83, 85, 169), chronic and acute methanol poisoning (13, 144, 189), and Aspartame toxicity (54, 58, 93, 181), are in all ways identical.
There is nothing that happens to the human body from the toxic effect of methanol that has not been expressed during the course of MS... nothing (143, 144).
This generalization extends even to the remarkable opthomological conditions common to both: transitory optic neuritis and retrolaminar demyelinating optic neuropathy with scotoma of the central visual field (which occasionally manifests as unilateral temporary blindness (85, 138, 163).
In fact, these opthomological symptoms have been thought of for years in their respective literatures to be "tell tale" indications for the differential diagnosis for each of these maladies independently (85, 138, 148, 163, 169).
The common symptoms of
headache (13, 83, 181, 189)
nervousness (13, 83, 181)
depression (58, 83, 189, 181)
memory loss (18, 147, 85, 169, 181)
tingling sensations (13, 85, 168, 138, 169)
pain in the extremities (13, 85, 169)
optic neuritis (85, 138, 148, 163, 169)
bright lights in the visual field (139, 83)
seizures (21, 83, 160)
inability to urinate or to keep from urinating (139, 146, 167)
are all shared by each of these conditions and shared yet again by complaints from aspartame poisoning(54, 58, 93, 181).
I take these strikingly similar symptom patterns as evidence that these disorders act on identical components of the central nervous system and in the same way.
The "Miracle" that MS shares with Methanol poisoning
In the early stages of MS, or when a non-lethal dose of methanol has been administered, complete recovery is a possibility.
The only two afflictions for which such dramatic "remissions" are reported from identical neuromuscular and opthomological damage, even "blindness" is relapsing-remitting multiple sclerosis (85) and methyl alcohol poisoning (138, 163).
The pathology of the two maladies is in may ways identical, particularly when it comes to destruction of the myelin sheath with no harm to the axon itself (18, 148, 176).
Sex Ratios for MS and Aspartame Reactions
Women bear the brunt of multiple sclerosis (91a-c) and lupus (SLE)(73) with fully three-fold representations in infliction numbers over men for both diseases.
This is exactly the proportion represented by adverse reactors to Aspartame reported by the US Center for Disease Control in their study of 1984 (58).
The Center found three women to every man whose aspartame consumption complaints were serious enough to warrant investigation (93).
Although the female/male ratio for those stricken with MS has always been high, recent estimates place it at over 3 to 1 (91, 91a, 91c).
What might account for the difference across sexes in incidence?
A study published in the New England Journal of Medicine (94) reports biopsies of the gastric lining of men and women.
A result was that the concentration of ADH in the gastric lining of men was much higher than for woman.
Men have the advantage of removing methanol from the bloodstream four times faster on an equal-body-size basis than women.
Thus, for men, methanol is more likely to be removed from the blood before it reaches the brain.
The brain is spared but the methanol removed would still be metabolized to formaldehyde in the gut where it would reap its havoc on a more forgiving organ.
This may help explain why men have more gastrointestinal complaints from both methanol and Aspartame consumption (93, 99).
On the other hand, women's complaints from both more frequently involve serious neurological complications."...
______________________________________________
Rich Murray, MA
Boston University Graduate School 1967 psychology
BS MIT 1964, history and physics
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