By James Bowen, M.D.

Posted: 27 February 2005

Aspartame is such a heinous poison the FDA stopped counting, after reporting 92 known symptoms caused by Aspartame. Not that, new accounts of human degradations are not still pouring in to the FDA. They are just no longer being acknowledged. We're not talking about minor issues: Examples are Diabetics being made horribly worse by diets containing Aspartame, which their doctors have prescribed for them. Some even get over their diabetes once off all Aspartame products. Brain tumors, (The initial toxicity studies showed Aspartame to be the number one brain carcinogen known to man, and even at very low doses!), Neurodegenerative disease (Please see the recent documentary by Sound And Fury Productions, Tucson, Arizona "Sweet Misery: A Poisoned World" - Go to for more information), every type of autoimmune disease, and on and on.

Below you will find web sites where many of my reports are posted and the FDA Report of 92 symptoms, audit (Bressler Report) and even damning Center for Disease Control investigation. The protest of the National Soft Drink Association shows the pop companies knew the gun was loaded before they ever used this neurotoxin. Please see for a complete listing of what the FDA did recognize before Dr Hyman Robert's medical text: Aspartame Disease: An Ignored Epidemic, will give far deeper detail than what I mention here. The Aspartame Toxicity Center, is exhaustive on Aspartame toxicity, and politics. How can I know, believe and feel this is a God given ministry laid upon me? Let's look at how this one chemical: N-methyl, L-aspartyl, phenylalanine causes such human devastation! A brief look at what it is biochemically:

The N-methyl corner of this carefully crafted, three cornered poison is methyl alcohol, or wood alcohol (methanol), is well known for over a century to cause death, dementia, insanity, carcinogenesis, degenerative diseases, and autoimmune disease of every body system, blindness, and death. Methanol is sequentially metabolized via obligatory human metabolism into formaldehyde, formic acid, and carbon monoxide.

All of these materials are human sensitization agents, and CHz (Chemical hypersensitivity disease) plagues Aspartame's victims for the rest of their lifetimes, even long after they have stopped ingesting Aspartame, as does the MtDNA damage.

Methanol is a recognized cause of many diseases including blindness, pancreatitis, and demyelinization type neurodegenerative diseases, etc. Exposure of mothers to even minute trace amounts of methanol is recognized as the cause of severe fetal malformations! Not surprisingly, about half of those doctors who deliver babies in our country, advise pregnant women with great urgency to never expose themselves to Aspartame, because of its enormous damage to the fetus. Surprisingly, about half are still oblivious, and tell their pregnant patients to use Aspartame freely, and without worry.

Methanol has obligatory metabolism to formaldehyde (embalming fluid). Formaldehyde is the strongest organic base, and is a polymerizing agent. That is, it turns proteins into chains of proteins by chemically joining them together. This process is called esterization. The proteins, when esterized with each other, then are plastics. This is called "polymerization." This is why formaldehyde is so effective to embalm the dead. It turns cadavers into plastics, which have a very long "Shelf life." Formaldehyde is a very commonly used plasticizing agent, and a very powerful one.

When Aspartame is consumed by the human, it is known to plasticize even the very DNA of which our genes are composed. This is called "cross linking DNA", for which formaldehyde is famous.

When the Aspartame molecule exists in its diketopiperazine (DKP) form, it is from that DKP configuration, an extremely strong plasticizing agent. Diketopiperazines of many types are the major powerful, far reaching substrates of the plastics industry. It was the diketopiperazine form of Aspartame, which was found to be the number one brain tumor carcinogen known to man. Probably because, in that form, the molecule is adsorbed as the intact molecule, and because that form is an even more extremely potent polymerizer, which can reach farther, and with more energy than can formaldehyde to esterise human substances into polymers, and to cross link DNA.

All of this "denatures" human tissue making it into something very different, but in many ways just like the human tissues it was made from.. This is very confusing to the immune system. (See "Aspartame Murders Infants") When the human immune system decides to attack and destroy this denatured tissue, it is at the same time attacking and destroying human tissue. This is "autoimmune disease." Something we all do not want to happen to our bodies. Arthritis, lupus, neurodegenerative disease, infertility, allergies, premature aging, atherosclerosis, and every sort of "connective tissue" diseases, are the result of letting Aspartame do this to our bodies.

I have seen patients, in whom only six weeks of using Aspartame destroyed all the cartilage in their bodies, leaving them horribly disabled and deformed. I used Aspartame in the Diet Kool Aid for six weeks, and had horrible neurodegenerative disease, with a Lou Gehrig's picture. I went from having a full head of dark brown hair, to in just six weeks having the appearance of having dyed my hair dark brown, and now the gray roots were showing. This happened because of the immense Mt DNA, and mitochondrial damage from Aspartame.

This graying was also the result of formic acid effect. Formaldehyde is quickly metabolized to formic acid (fire ant poison). Formic acid (or formate) immediately shatters your DNA molecules, leaving your DNA unable to do anything, so the cell dies, leaving the formate free to diffuse from cell to cell, killing every cell, until it's too dilute to shatter. This is why it is known as a "blister poison". It kills whole groups of cells, leaving only blisters of dead tissue. Even when too dilute to kill the cell outright, it can cause immense genetic damage in the cell. This also happens in the immune system leaving it compromised and de-focused. This increases the tendency towards auto immunity, right along with the damage to the rest of your tissues, which are being denatured by all of this toxic reactivity. A fire ant can, with one sting, kill a human being that weighs millions of times more than itself. This points out how potent the formate poisoning can be when accompanied by hypersensitivity, CHz, Chemical Hypersensitivity disease. To recapitulate: the formic acid sting from fire ants, even though they weigh millions of times less than the human they attack, almost always raises a blister, because that sting has killed millions of cells, and sometimes kills the human being, resulting from the CHz reaction to the formic acid.

Formic acid is metabolized to carbon dioxide, If there is adequate folic acid (or folate) available, on a molecule per molecule basis, to do so. Metabolizing formate to carbon dioxide consumes one molecule of folate per every molecule of formate eliminated. The consumption of Aspartame therefore leads to the metabolic consumption of massive amounts of folic acid (folate), creating a deficiency of this essential vitamin. Inadequate folic acid leads to serious adult diseases, and results in grievous fetal malformations. When folate is not available, on a molecule per molecule basis, formic acid is metabolized to carbon monoxide, another serious poisoning.

L-aspartyl refers to aspartic acid, the little sister of glutamic acid or monosodium glutamate. Like monosodium glutamate, aspartic acid is a neural excitotoxin. That is aspartic acid, or aspartate, stimulates nerve cells to death. These neural excitotoxins (Chemically they are known as "dicarboxylic amino acids.") do not cross the blood brain barrier. They are preferentially secreted into the CSF, (cerebrospinal fluid) by the choroids plexus, a vascular plexus in the anterior aspect of the ventricles, (the cavities inside the brain), and pass on out posteriorly, exiting over the back of the spinal column, and brain stem from the end of the fourth ventricle.

During this trip out, the CSF passes from the third ventricle to the fourth ventricle through a narrow tube known as the Sylvian Canal. This canal ends in the roof of the forth ventricle, so the CSF stream is jetted across the fourth ventricle against the floor of the fourth ventricle, just like water directed from a fire hose will spray against a building. Only in the case of the Aspartame victim, the stream of CSF is carrying with it destruction from its load of excitotoxins.

The hypothalamus is located in floor of the fourth ventricle. It is the coordinator of the master gland of the neuroendocrine system, the pituitary gland. The hypothalamus is heavily damaged by this stream of excitotoxins from Aspartame. The white matter lining the ventricles, and the nuclei and tracts of the brain steam and upper spinal cord are heavily damaged by this excitotoxin in the CSF as well. They are by this secretory process, richly bathed in CSF to nourish them, but in the case of Aspartame, it is also destroying them, along with their vital myelin sheaths and nuclei.

This Aspartame neuro endocrine damage in the female is often accompanied by a rapid onset of amenorrhea and infertility, soon after beginning the consumption of Aspartame. Consumption frequently results in premature menopause. Every step in the reproductive cycle, starting with the gleam in daddy's eye, is destroyed by Aspartame toxicity. Phenylalanine is the toxic one of the ten essential amino acids. It also out competes the other amino acids at enzyme sites in the body. All amino acid biochemistry occurs at enzyme sites designed to do just whatever that one specific process is with amino acids.

A disease called Phenylketonuria (PKU) exists when the brain has insufficient enzymatic capacity to handle phenylalanine via the usual enzymatic channels. The phenylalanine is then metabolized via accessory enzyme channels, producing neurotoxins that are destructive of the brain tissue. You give a baby with PKU, a dish of beans, which is rich in phenylalanine, and you will have thereby accomplished so much brain destruction the baby will ever after be severely retarded. You get about as much phenylalanine from a can of Aspartame pop, as you do from a plate of beans. From the plate of beans you get it over about twenty hours, and in competition with about twenty other amino acids.

Remember, all amino acid biochemistry is competitive at enzyme sites in the body. Phenylalanine is the amino acid, which out competes all the others at enzyme sites! From the can of Aspartame pop, you get that phenylalanine in about five minutes, in competition with nothing, but accompanied by the excitotoxin, aspartic acid. The liver is immediately flooded by this phenylalanine isolate. Amino acid isolates are not like nutritional amino acids at all, because nutritional amino acids are provided and metabolized in harmony as a balanced mix, while amino acid isolates on the other hand, drive specific and often toxic processes in the body. Amino acid isolates are at best pharmaceuticals, and at worst, horribly damaging toxins.

Amino acid release from the liver is enzymatic, and phenylalanine is the one which out competes all the other amino acids at enzyme sites, so you get an immediate flood of phenylalanine into the peripheral blood from a can of NutraSweet pop. The blood brain barrier is also enzyme linked, so you immediately, in like manner, flood the brain with phenylalanine. There are three severe toxic effects from this flood of phenylalanine into the brain:

First: You are creating selective malnutrition of the brain, by holding up the balanced mixture of amino acids which it needs for proper growth, repair, and function, at the blood brain barrier. The high dose of phenylalanine simply out competes the normal, nutritious amino acid mixture, denying it passage into the brain.

Second: You are creating the PKU effect in your own brain. You have created an excess of brain phenylalanine, in excess of what your brain can handle via its normal enzyme channels, so the excess phenylalanine is being metabolized via accessory abnormal enzyme channels into potent neurotoxins. In a child with a still developing brain, this leads to severe structural, and pervasive brain damage. In the adult also, it leads to brain dysfunction, and damage.

Third: We make neurotransmitters in the brain. The first step in this process is the decarboxylation of an amino acid to its amine, at the decarboxylase enzyme sites. In simple words, you pull a carbon dioxide molecule off the amino acid molecule. This flood of the over competing phenylalanine blocks the intended decarboxylation of other amino acids at these sites, which deprives your brain of badly needed neurotransmitters.

For Example: You do not decarboxylate tyrosine to tyramine, which is the first step in forming dopamine. Dopamine is the rose colored glasses for which menopausal women are so famously lacking. So you are deficient in dopamine. This produces depression, and loss of the ability to feel good about anything, your life, your job, or your spouse.

Likewise: You do not decarboxylate tryptophane to tryptamine, the first step in producing serotonin. So you are deficient in Serotonin in some areas of the brain, and different compensatory metabolic routes lead to serotonin excess in others. Serotonin is the leadership hormone. It gives you nervous energy, self-confidence, the ability to work under stress, and enjoy working under stress. It also runs your carbohydrate metabolism, and feeds back to your neuroendocrine system. With these two neurotransmitters down, along with the other Aspartame neurotoxicities, you are a brain washed idiot. Too befuddled and lost to even think independently, or care about anything outside yourself.

The fourth well-known toxicity of Aspartame is that it is a potent chelating agent. The FDA told the manufacturers, thirty years ago, that this fact alone would never allow Aspartame's approval for human beings, because it rapidly chelates the heavy metal poisons from any metal or ceramic container it is poured into, and carries those heavy metal poisons right into the body. Because they are in chelated form, those heavy metal poisons are highly adsorbed from the digestive tract. Aluminum is not even absorbed from the digestive tract unless it is chelated. My friends, who deliver pop and service pop machines, tell me that sugar pop never eats its way through the aluminum cans. It is always the Aspartame pop that chelates its way through the aluminum can, and makes a mess. Billions of cans of Aspartame pop, rich in toxic chelated aluminum, are being consumed every year. Is it any wonder that we are seeing an epidemic of Alzheimer's disease?

Alzheimer's dz, Arteriosclerosis, Aging, Brain Damage, and many other degenerations of the human organism are well known to be related to ingesting of toxic heavy metals like aluminum, arsenic, barium, cadmium, lead, mercury, thorium, thallium, etc. The list of heavy metal poisons is long, it goes on and on, but the results are always devastating. You assure yourself of ALL these poisonings by consuming Aspartame. Heavy metal poisonings, of course, are even more devastating to fetuses, babies, and developing children.

We really, have just begun to look at the toxicity of Aspartame. In the human digestion, the adsorption of the intact molecule, and its DKP, along with ten known other break down, isomerisation, and cyclisization products are known to occur. Many of these poisonings are synergistic, meaning that they greatly increase the damages to the human organism by helping each other, and greatly multiplying the damage, than if they occurred alone, which would still yield enormous human destruction. All of these damage the bone marrow, which produces the blood elements resulting in blood diseases like Lupus Erythematosis. The blood also becomes loaded with toxic metabolites. Methanol poisoning is famous as a cause of acidosis, and acidemia. Formate ties up the hemoglobin in the bone marrow so it cannot carry oxygen to the tissues: Just like carbon monoxide, cyanide, and fluoride.

The damage to mitochondria, for example, is extreme. You are now acquainted with the methanol-formaldehyde-formic acid toxic axis, and are cognizant of the extreme damage to tissue, and genes that it causes. In the cell, this starts with the metabolism of methanol to formaldehyde. This is the only way methanol can be metabolized in the human organism. Other animals, except primates, have ways of handling this step without toxicity, so the extreme Aspartame toxicity found in lower animals is far less than that done to humans. Phenylalanine toxicity likewise: Because in them the phenylalanine is metabolized outside the brain in lower animals, it doesn't generate a neurotoxin directly in the brain. None the less, the amount of these poisons actually dosed in FDA testing of animals is far lower than the allowable limits for humans would require in testing the animal, and they still produce striking ill effects in the animals tested, at far lower doses than specified by law.

FDA regulations required the test animals to ingest far greater doses without any harm, before Aspartame could ever be approved for ingestion for human consumption. The law protecting humans has never been followed by the FDA in the aspartame approval process! Rumsfeld callously devastated humanity when ignoring direct striking scientific evidence demonstrating the human devastations resultant from Aspartame use! Don Rumsfeld was CEO of Searle and said he would call in his markers to get it approved. Don't miss the movie Sweet Misery which tells how he accomplished this.

The cellular metabolism of methanol to formaldehyde to formic acid, occurs 25% percent in the cytosol (cell body) of the cell and 75% in the mitochondria of the cell. This represents a huge increase in mitochondrial exposure to these toxins, because the mitochondria would typically amount to no more that 1% to 5% of the cellular volume. Moreover, the nuclear DNA is not directly exposed to these metabolic processes. The mitochondria are the minute furnaces of the cell, which burn foods, and provide the cell with energy, via substances like ATP, which can be safely used by the rest of the cell. If mitochondrial enzymatic processes leak out of the mitochondria, it kills the cell just like a fire would kill a living organism. If the mitochondrial processes are impaired by toxins, like those from Aspartame, it leads to the production of super oxide free radicals, which damage the cells, and the mitochondria themselves, and rapidly age the person.

Nuclear DNA is protected with a double walled sheath inside the nucleus, and few of these toxins are usually allowed near it at any concentration like that occurring in the mitochondria. The nuclear DNA has enormously effective repair processes working upon it to maintain it in pristine condition. Mitochondrial DNA, by way of comparison, has little by way of protection. It is directly exposed to the formaldehyde and formic acid destructions, and has but little by way of repair mechanisms. The maximum repair to mitochondrial DNA is merely the excision of damaged segments. Any free radicals generated, because of the inadequate genetic guidance occurring as a result of this disordered and deficient DNA, further degenerate the mitochondria, as well as aging the organism. Anti Mitochondrial anti bodies are a new phenomenon, only recognized since the exposure of the human organism to Aspartame, just one of the many epidemic human autoimmune diseases it causes.

Not surprising then, that we have an epidemic of MtDNA (Mitochondrial DNA) diseases since the release of Aspartame for human consumption. Some of these are: Diabetes (Its incidence jumped 30% the first six months after Aspartame was released for use in soft drinks.) Graying (There were no hair dyes designed for men when I went looking for them. I was a leader of a great crowd of men that now use them, and there are many brands now available just for men.) Chronic Fatigue and Polymyalgia. The Chronic Fatigue/Polymyalgia study in Portland Oregon was defunded in 1992, because it found nothing consistently associated with Chronic Fatigue/Polymyalgia, except Aspartame consumption. Anti Mitochondrial Antibody Diseases. Pervasive developmental disorders like autism and attention deficit are now epidemic, and rampant!

Any one wanting a more exhaustive breakdown of these mitochondrial diseases, which are now epidemic, can use the Internet to look up the extensive medical analysis and description of theses "new diseases" which have come upon us with the advent of Aspartame. Web sites and book resources below.

I had Dr Schull, then Professor Jan Smith, at North Texas University in Fort Worth, arrange to measure the amount of chelated aluminum carried out of the can into the human body. Dr Smith was fired on the spot, and the biochemistry professor who had tenure, was ordered to scrap the procedure immediately, and never set up that procedure again!

Any intelligent human being will know that a primary concept of good hygiene is: "First do no harm." Jehovah God urges this upon us as a duty to Him: TO PROTECT AND CARE FOR THE BODY HE HAS GIVEN US. He also commands us to love and care for every other human being, just as we would our own bodies! Any question why I consider this a God given ministry?

"The watchman on the wall who sees danger, yet does not sound the trumpet or help his fellow man, will have the blood of the injured on his hands." From Ezekiel 33:6 (FDA TAKE NOTE!)

James Bowen, M.D.


Web Sites: Click on aspartame

Aspartame Toxicity Center:

Medical text on the global plague of Aspartame Disease by H. J. Roberts, M.D. Aspartame Disease: An Ignored Epidemic, or 1-800-827-7991 over 1000 pages of symptoms, diseases and drug interactions. Web site has other books and tapes on the subject.

Books by neurosurgeon Russell Blaylock, M.D., Excitotoxins: The Taste That Kills and Health & Nutrition Secrets to Save Your Life, etc.

Official WNHO Aspartame Information Group:

Recent Important Reports: What To Do If You Have Used Aspartame and the MS and Aspartame Connection by Dr. Russell Blaylock -

New movie exposing how aspartame has poisoned the world, and what it took to get it approved: Sweet Misery: A Poisoned World ( and visit for more information on the movie

24 page booklets for distribution on aspartame, Artificially Sweetened Times (contact )