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Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells
BMC Neuroscience 2007 Jan 23, 8(1): 9 doi: 10.1186/1471-2202-8-9
Chunlai Nie niecl1022@ioz.ac.cn
Xing sheng Wang step@sun5.ibp.ac.cn
Rongqiao He herq@sun5.ibp.ac.cn
ISSN 1471-2202
Article type Research article
Submission date 15 August 2006
Acceptance date 23 January 2007
Publication date 23 January 2007
Article URL http://www.biomedcentral.com/1471-2202/8/9
Chun Lai Nie 1,3
Xing Sheng Wang 1,3
Ying Liu 1
Sarah Perrett 2 and
Rong Qiao He 1,3*
1 State Key Laboratory of Brain and Cognitive Science
Institute of Biophysics, 15 Datun Rd, Chaoyang District, Beijing 100101, China
2 National Laboratory of Biomacromolecules
District, Beijing 100049, China
*Corresponding author
http://groups.yahoo.com/group/aspartameNM/message/1406
Addict Biol. 2005 Dec;10(4): 351-5.
Concentration changes of methanol in blood samples during an experimentally induced alcohol hangover state.
Woo YS, Yoon SJ, Lee HK, Lee CU, Chae JH, Lee CT, Kim DJ.
Chuncheon National Hospital, Department of Psychiatry
The Catholic University of Korea, Seoul, Korea.
http://www.cuk.ac.kr/eng
sysop@catholic.ac.kr
Songsin Campus: 02-740-9714
Songsim Campus: 02-2164-4116
Songeui Campus: 02-2164-4114
http://www.cuk.ac.kr/eng/sub055.htm eight hospitals
http://groups.yahoo.com/group/aspartameNM/message/1394
" Absorbed formaldehyde can be oxidized to formate and carbon dioxide
or can be incorporated into biologic macromolecules. "
[ References include: Soffritti M, Belpoggi F, Lambertini L, Lauriola M, Padovani M, Maltoni C. 2002. Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats. Ann NY Acad Sci 982: 87-105.
Soffritti M, Maltoni C, Maffei F, Biagi R. 1989. Formaldehyde: an experimental multipotential carcinogen. Toxicol Ind Health 5:699-730. "Morando Soffritti is a member of the Working Group.]
http://www.ehponline.org/members/2005/7542/7542.html free full text
After a thorough discussion of the epidemiologic, experimental, and other relevant data, the working group concluded that formaldehyde is carcinogenic to humans, based on sufficient evidence in humans and in experimental animals.
In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, "strong but not sufficient" evidence of leukemia, and limited evidence of sinonasal cancer.
The working group also concluded that 2-butoxyethanol and 1-tert-butoxy-2-propanol are not classifiable as to their carcinogenicity to humans, each having limited evidence in experimental animals and inadequate evidence in humans.
These three evaluations and the supporting data will be published as Volume 88 of the IARC Monographs. PMID: 16140628
Environ Health Perspect. 2005 Sep; 113(9): 1205-8.
Meeting report: summary of IARC monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.
Cogliano VJ, Vincent James Cogliano cogliano@iarc.fr
Grosse Y, Yann Grosse grosse@iarc.fr
Baan RA, Robert A. Baan baan@iarc.fr
Straif K, Kurt straif@iarc.fr
Secretan MB, Marie B rice Secretan secretan@iarc.fr
El Ghissassi F, Fatiha El Ghissassi elghissassi@iarc.fr
Working Group for Volume 88.
IARC, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France
Tel: +33 (0)4 72 73 84 85 - Fax: +33 (0)4 72 73 85 75
IARC 2004 - All Rights Reserved
http://monographs.iarc.fr
cie@iarc.fr
Monographs Recently Published
IARC Monographs Vol 88
Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol
December 2006
478 pages
ISBN 92 832 1288 6
US$ 40
This volume re-evaluates the available evidence on the carcinogenic potential of formaldehyde, a substance that is found in the workplace and in the environment. Formaldehyde is widely used in resins that bind wood products, pulp and paper; in glasswool and rockwool insulation; in plastics and coatings, textile finishing, chemical manufacture; and as a disinfectant and preservative. Also evaluated are two glycol ethers, 2-butoxyethanol and 1-tert-butoxypropan-2-ol, which are widely used as solvents in paints and paint thinners, coatings, glass and surface cleaners, inks, adhesives, personal-care products, and as chemical intermediates. As for formaldehyde, there is sufficient evidence in epidemiological studies for nasopharyngeal cancer, strong but not sufficient evidence for leukaemia, and limited evidence for sinonasal cancer. The extensive scientific database on the mechanisms by which formaldehyde can induce nasal-tract cancer in humans is considered. These data provide strong support for the empirical observation of nasopharyngeal cancer in humans. In contrast, the lack of information on possible mechanisms by which formaldehyde might increase the risk for leukaemia in humans tempered the interpretation of the epidemiological data on that cancer. Although this volume focuses on a qualitative assessment of the carcinogenic potential of formaldehyde, subsequent predictions of the risks for nasopharyngeal cancer should consider pertinent information on mechanisms of carcinogenesis, including genotoxicity and dose-dependent cytoxicity. A theme common to the three evaluations is the consideration of mechanistic information to develop and evaluate hypotheses on the sequence of steps that lead to the induction of tumours in experimental animals. The hypothesized mechanisms described provide an interesting set of cases that range from a vast literature on respiratory tract tumours in rats induced by the inhalation of formaldehyde to some more tentative hypotheses on the various tumours observed in animals following exposure to both glycol ethers. Recurring issues were the criteria that characterize a rare tumour or how to introduce additional information to resolve difficult questions; for example, how to consider the results of historical controls.
International Agency for Research on Cancer, Lyon, France.
An international, interdisciplinary working group of expert scientists met in June 2004 to develop IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.
Each IARC Monograph includes a critical review of the pertinent scientific literature and an evaluation of an agent's potential to cause cancer in humans.
Key words: 1-tert-butoxy-2-propanol, 2-butoxyethanol, carcinogen, formaldehyde, glycol ethers, hazard identification, IARC Monographs, leukemia, nasopharyngeal cancer, sinonasal cancer. Environ Health Perspect 113: 1205-1208 (2005). doi:10.1289/ehp.7542 available via http://dx.doi.org [Online 12 May 2005]
Address correspondence to V.J. Cogliano
Carcinogen Identification and Evaluation
International Agency for Research on Cancer, 150 cours
Albert Thomas
69372 Lyon cedex 08, France.
33-4-72-73-84-76. fax 33-4-72-73-83-19
cogliano@iarc.fr
The Working Group for Volume 88 of the IARC Monographs includes:
Ulrich Andrae (Germany)
Dr. Ulrich Andrae
GSF-Institut f ikologie,. Postfach 1129, D-85758 Neuherberg, Germany
Fax: 149-089-3187-3449
Sherwood Burge (UK)
andrae@gsf.de
Rajendra S Chhabra (USA)
http://dir.niehs.nih.gov/dirtob/chhabra.htm
General Toxicology Group, TOB, ETP, DIR
chhabrar@niehs.nih.gov
John Cocker (UK)
Health and Safety Laboratory, Buxton, UK
john.cocker@hsl.gov.uk
David N Coggon (UK)
MRC Environmental Epidemiology
Unit at the University of Southampton, UK
dnc@mrc.soton.ac.uk
Rory Conolly (USA)
Senior Research Biologist
National Center for Computational Toxicology, Office of Research and Development
U.S. Environmental Protection Agency
Rconolly@ciit.org
Paul Demers (Canada)
Occupational Hygiene Institute
University of British Columbia
pdemers@unixg.ubc.ca
David A Eastmond (USA)
Environmental Toxicology Graduate Program
University of California
Riverside, CA 92521
(951) 827-4497 (Voice) (951) 827-3087 (Fax)
david.eastmond@ucr.edu
Elaine Faustman (USA)
Professor, Env. and Occ. Health Sciences, Adjunct Professor
Evans School
206-685-2269
faustman@u.washington.edu
Victor J Feron (the Netherlands)
TNO Nutrition and Food Research (retired)
The Netherlands TNO-CIVO TOXICOLOGY AND NUTRITION INSTITUTE
Utrechtseweg 48 3704 HE Zeist The Netherlands
(31)-3404 44 144
Michel G n (Canada, Chair)
Departement de medecine du travail et d'hygiene du milieu
Universite de Montreal
Quebec, Canada
gerinm@ere.umontreal.ca
Marcel Goldberg (France)
France -- National Institute of Health and Medical Research INSERM
Unite 88, HNSM 14 Rue de Val d'Osne F-94410 St. Maurice France
[33] 1-451-83859 [33] 1-451-83889
Departement Sante Travail, Institut de Veille Sanitaire
12, rue du Val d'Osne, 94410 Saint Maurice, France
marcel.goldberg@st-maurice.inserm.fr
Bernard D Goldstein (USA)
Director of the Environmental and Occupational Health Sciences Institute and Professor and Chair of the Department of Environmental and Community Medicine at UMDNJ - Robert Wood Johnson Medical School.
Dean's Office
University of Pittsburgh Graduate School of Public Health
A624 Crabtree Hall, 130 DeSoto St.
Pittsburgh, PA 15261, USA
bdgold@pitt.edu
Roland C Grafstr (Sweden)
Roland C Grafstr Institute of Environmental Medicine, Karolinska Institutet
Box 210, S−17177 Stockholm, Sweden
Telefax: +46-8−329402
roland.grafstrom@imm.ki.se
Johnni Hansen, PhD (Denmark)
Senior Researcher
Danish Cancer Registry
Institute of Cancer Epidemiology
Danish Cancer Society
Strandboulevarden 49, DK-2100, Copenhagen, Denmark
johnni@cancer.dk
Michael Hauptmann (USA), The National Cancer Institute
Kathy Hughes (Canada), Head, Existing Substances Section 1, Health Canada
Ted Junghans (USA)
Technical Resources
International, Inc.
6500 Rock Spring Drive, Suite 650
Bethesda, MD 20817, USA
tjunghans@tech-res.com
Dan Krewski, MHA, MSc, PhD (Canada)
Professor Director, R. Samuel McLaughlin
Centre for Population Health Risk Assessment, Institute of Population Health
1 Stewart Street, Room 320
Phone: (613) 562-5381
Fax: (613)562-5380
dkrewski@uottawa.ca
Steve Olin (USA)
ILSI International Life Sciences Institute
solin@ilsi.org
Martine Reynier (France)
Mme Martine REYNIER
Institut National de Recherche et de S rit INRS)
30, rue Olivier Noyer, 75680 Paris Cedex 14 (France)
Tel : +33 (0)1 40 44 30 81
Fax : +33 (0)1 40 44 30 54
martine.reynier@inrs.fr
Judith Shaham (Israel)
Morando Soffritti (Italy)
Leslie Stayner (USA)
Patricia Stewart (USA)
Douglas Wolf (USA) , wolf.doug@epa.gov, DVM, PhD, USEPA, (Toxicology)
We gratefully acknowledge the important contributions of the administrative staff of the IARC Monographs: S. Egraz, M. L re, J. Mitchell, and E. Perez. The IARC Monographs are supported, in part, by grants from the U.S. National Cancer Institute, the European Commission, the U.S. National Institute of Environmental Health Sciences, and the U.S. Environmental Protection Agency. The authors declare they have no competing financial interests. Received 31 August 2004; accepted 12 May 2005.
[ see also:http://groups.yahoo.com/group/aspartameNM/message/1458
The EU Parliament voted July 12 to ban artificial sweeteners in newly born and infant foods.
On May 15 four huge UK supermarket chains announced bans of aspartame and MSG, food dyes, and many additives to protect kids from ADHD -- Sainsbury, Tesco, Marks & Spencer, and ASDA, a unit of WalMart.
May 31: Coca-Cola and the much larger Cargill Inc., after years of secret development, with 24 patents, will soon sell rebiana (stevia) in drinks and food in the many nations where it is approved as a sweetener -- for decades a major sweetener in Japan, China, Korea, Taiwan,
Thailand, Malasia, Saint Kitts, Nevis, Brazil, Peru, Paraguay, Uruguay, and Israel, and an approved supplement in USA, Australia, and Canada, according to Wikipedia.
"Of course, everyone chooses, as a natural priority, to actively find, quickly share, and positively act upon the facts about healthy and safe food, drink, and environment."
Rich Murray, MA
http://groups.yahoo.com/group/aspartameNM/message/1453
http://groups.yahoo.com/group/aspartameNMmessage/1451
http://groups.yahoo.com/group/aspartameNMmessage/1437
http://groups.yahoo.com/group/aspartameNM/message/1427
http://groups.yahoo.com/group/aspartameNM/message/1426
http://groups.yahoo.com/group/aspartameNM/message/1438">http://groups.yahoo.com/group/aspartameNM/message/1438
National Institute of Occupational and Environmental Health
Raanana, Israel. MD
Occupational Cancer Unit, Occupational Health & Rehabilitation Institute
P.O. Box 3, Raanana 43100, ISRAEL
yshaham@bezeqint.net
European Foundation of Oncology and Environmental Sciences
B. Ramazzini Cesare Maltoni Cancer Research Center
Bologna, Italy
crcfr@ramazzini.it
Division of Epidemiology and Biostatistics
University of Illinois at Chicago School of Public Health (M/C 923)
1603 West Taylor Street, Room 971
Chicago, IL 60612
E-mail: lstayner@uic.edu
National Food Safety and Toxicology Center
165 Food Safety and Toxicology Building
Michigan State University
East Lansing, MI 48824
Fax (517) 432-2310
http://groups.yahoo.com/group/aspartameNM/message/1417
http://groups.yahoo.com/group/aspartameNM/message/1457
Aspartame bans, tis more an avalanche than a trend...: Rich Murray 2007.08.17
ASDA, Wal-Mart's UK supermarket chain, bans artificial colors, trans fats, MSG and aspartame, Marguerite Kelly, The Washington Post: Murray 2007.08.03 ]
So far, USA print and broadcast media are deaf, blind, and dumb, regarding recent major bans of aspartame and MSG in the UK and EU.
http://groups.yahoo.com/group/aspartameNM/message/1454
Recent research and news re aspartame and stevia: Murray 2007.08.16
Room For All
rmforall@comcast.net
505-501-2298
1943 Otowi Road
Santa Fe, New Mexico 87505
http://groups.yahoo.com/group/aspartameNM/message/1395
Aspartame Controversy, in Wikipedia democratic encyclopedia, 72 references (including AspartameNM # 864 and 1173 by Murray, brief fair summary of much more research: Murray 2007.01.01
Souring on fake sugar (aspartame), Jennifer Couzin, Science 2007.07.06: 4 page letter to FDA from 12 eminent USA toxicologists re two Ramazzini Foundation cancer studies 2007.06.25: Murray 2007.07.18
Artificial sweeteners (aspartame, sucralose) and coloring agents will be banned from use in newly-born and baby foods, the European Parliament decided: Latvia ban in schools 2006: Murray 2007.07.12
Stevia to be approved and cyclamates limited by Food Standards Australia New Zealand: JMC Geuns critiques of two recent stevia studies by Nunes: Murray 2007.05.29
more from The Independent, UK, Martin Hickman, re ASDA (unit of Wal-Mart Stores) and Marks & Spencer ban of aspartame, MSG, artificial chemical additives and dyes to prevent ADHD in kids: urray 2007.05.16
http://news.independent.co.uk/uk/health_medical/article2548747.ece
ASDA (unit of Wal-Mart Stores WMT.N) and Marks & Spencer will join Tesco and also Sainsbury to ban and limit aspartame, MSG, artificial flavors dyes preservatives additives, trans fats, salt "nasties" to protect kids from ADHD: leading UK media: Murray 2007.05.15
Coca-Cola and Cargill Inc., after years of development, with 24 patents, will soon sell rebiana (stevia) in drinks and foods: Murray 2007.05.31
